The Duffy blood group system
نویسندگان
چکیده
منابع مشابه
The Duffy blood group system: a review.
Duffy was the first blood group mapped to an autosome (chromosome 1) using cytogenetic studies. Duffy antigens are located on a glycoprotein that can be found on erythrocytes and other cells throughout the body. Fy(a) and Fy(b) are products of their respective alleles (FY*A, FY*B). Fy(x) characterized by weak Fy(b) expression, is a result of an additional mutation in FY*B. The Fy(a-b-) phenotyp...
متن کاملA New Human Duffy Blood Group Specificity
The Duffy blood group system of human erythrocytes comprises a membrane glycoprotein recently characterized by immunoprecipitation techniques (1) . It is a polymorphic system that includes determinants for five alloantigens, two of which are Mendelian alleles (Fya and Fyb) (2, 3) . A null genotype, designated Fy(ab-) (4), lacks the expression of both Fya and Fyb, and is inherited as a third all...
متن کاملDuffy Blood Group Genotyping in Thai Blood Donors
BACKGROUND Duffy (FY) blood group genotyping is important in transfusion medicine because Duffy alloantibodies are associated with delayed hemolytic transfusion reactions and hemolytic disease of the fetus and newborn. In this study, FY allele frequencies in Thai blood donors were determined by in-house PCR with sequence-specific primers (PCR-SSP), and the probability of obtaining compatible bl...
متن کاملThe global distribution of the Duffy blood group
Blood group variants are characteristic of population groups, and can show conspicuous geographic patterns. Interest in the global prevalence of the Duffy blood group variants is multidisciplinary, but of particular importance to malariologists due to the resistance generally conferred by the Duffy-negative phenotype against Plasmodium vivax infection. Here we collate an extensive geo-database ...
متن کاملDuffy Blood Group System and the malaria adaptation process in humans
Malaria is an acute infectious disease caused by the protozoa of the genus Plasmodium. The antigens of the Duffy Blood Group System, in addition to incompatibilities in transfusions and hemolytic disease of the newborn, are of great interest in medicine due to their association with the invasion of red blood cells by the parasite Plasmodium vivax. For invasions to occur an interaction between t...
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ژورنال
عنوان ژورنال: Heredity
سال: 1950
ISSN: 0018-067X,1365-2540
DOI: 10.1038/hdy.1950.31